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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Mol Biochem Parasitol. 2010 Sep 16;175(2):95–103. doi: 10.1016/j.molbiopara.2010.09.001

Fig 1.

Fig 1

An integrated map of carbon flow through the metabolic network of Plasmodium falciparum. Arrows show the proposed direction of flux through the corresponding enzymatic reaction as suggested by experimental evidence; note that this is only intended to indicate net flux, and that the reaction in question might be reversible. Cofactors (ATP, NADH, etc.) are not shown for the sake of clarity. Text in circles represent major biomass components; the circled question mark indicates uncertainty about the existence of the enzyme transaldolase. Abbreviations: Glc, glucose; G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; F1,6BP, fructose-1,6-bisphosphate; DHAP, dihydroxyacetone phosphate; GADP, glyceraldehyde-3-phosphate; 1,3BPG, 1,3-bisphosphoglycerate; 3PG, 3-phosphoglycerate; 2PG, 2-phosphoglycerate; PEP, phosphoenolpyruvate; Pyr, pyruvate; Lac, lactate; Ac-CoA, acetyl-CoA; Ac-R, either acetate or acetyl-CoA; GlycP, glycerol-3-phosphate; Glyc, glycerol; Man6P, mannose-6-phosphate; Man1P, mannose-1-phosphate; GDP-Man, GDP-mannose; GlcN6P, glucosamine-6-phosphate; GlcNAc6P, N-acetyl-glucosamine-6-phosphate; GlcNAc1P, N-acetylglucosamine-1-phosphate; UDP-GlcNAc, UDP-N-acetyl-glucosamine; 6PGL, 6-phosphoglucono-δ-lactone; 6PGa, 6-phosphogluconate; Ru5P, ribulose-5-phosphate; R5P, ribose-5-phosphate; X5P, xylulose-5-phosphate; S7P, sedoheptulose-7-phosphate; E4P, erythrose-4-phosphate; Asp, aspartate; Gln, glutamine; Glu, glutamate; 2OG, 2-oxoglutarate; ICT, isocitrate; Cit, citrate; OAA, oxaloacetate; Mal, malate; Suc-CoA, succinyl-CoA; Suc, succinate; Fum, fumarate; GPI, glycophosphatidylinositol.