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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Bioconjug Chem. 2010 Feb 4;21(3):436–444. doi: 10.1021/bc9003102

Figure 3.

Figure 3

Uptake and imaging in MDA-MB-435 cells and xenograft tumors. (A) Uptake of 64Cu-DOTA/Cy5.5-2.5D in U87MG or MDA-MB-435 cells at 0.5, 1, and 2 hr. Blocking studies, indicated by “block”, were performed in parallel using a large molar excess of c(RGDyK). (B) MicroPET images of mice bearing subcutaneous MDA-MB-435 tumors at 1 hr and 24 hr post injection. Blocking experiments with unlabeled c(RGDyK) were performed to further demonstrate probe specificity.