Contralateral rotations and abnormal involuntary movements (AIMs) in A1, A2A and A1-A2A double KO mice compared to WT. Mice were treated daily with L-DOPA (2 mg/kg, i.p.) in combination with benserazide (2 mg/kg, i.p.) for 3 weeks. A, Contralateral turns in mice treated with L-DOPA. B, Total AIMs in mice treated with L-DOPA. Significant differences in the total AIMs in the plateau phase were observed between the WT (n=12) and the A1KO (n=9), or A2AKO (n=8) groups (p<0.05 for each comparison, Bonferroni correction).