Table 1.
Neurochemical measure of nigrostriatal innervation in wild-type and adenosine receptor KO mice chronically treated with L-DOPA after a unilateral 6-OHDA lesion
| Genotype | DA (pm/mg tissue) | DOPAC (pm/mg tissue) |
|---|---|---|
| WT (n=12) | ||
| Ipsilateral (lesioned) | 4.2 ± 1.4* | 0.0 ± 0.0* |
| Contralateral (intact) | 143.6 ± 7.5 | 11.3 ± 1.7 |
| A2A KO (n=9) | ||
| Ipsilateral (lesioned) | 4.3 ± 3.0* | 0.7 ± 0.5* |
| Contralateral (intact) | 129 ± 10 | 15.9 ± 7.4 |
| A1 KO (n=8) | ||
| Ipsilateral (lesioned) | 6.9 ± 3.0* | 0.4 ± 0.4* |
| Contralateral (intact) | 120 ± 14 | 9.7 ± 0.9 |
| A1-A2A KO (n=7) | ||
| Ipsilateral (lesioned) | 10.4 ± 8.2* | 1.2 ± 0.5* |
| Contralateral (intact) | 118 ± 18 | 9.6 ± 0.9 |
*
p < 0.05 versus respective contralateral (intact) striatum. The dopamine levels in the intact (right) side were not significantly different between wild-type and each of the three KO genotypes (p>0.05, Student’s t-test).