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. Author manuscript; available in PMC: 2012 Jan 7.
Published in final edited form as: Brain Res. 2010 Sep 7;1367:310–318. doi: 10.1016/j.brainres.2010.08.099

Table 2.

Neurochemical measure of nigrostriatal innervation in unilateral 6-OHDA-lesioned mice treated daily with L-DOPA following pretreatment with saline or caffeine (3mg/kg)

Treatment DA (pm/mg tissue) DOPAC (pm/mg tissue)
Saline (n=21)
 Ipsilateral (lesioned) 1.3 ± 0.6* 1.2 ± 0.4*
 Contralateral (intact) 82.5 ± 8.3 13.1 ± 6.5
Caffeine (n=24)
 Ipsilateral (lesioned) 3.6 ± 1.7* 0.3 ± 1.3*
 Contralateral (intact) 88.8 ± 10.6 14.8 ± 7.6
*

p < 0.05 versus respective contralateral striatum. The dopamine levels in the intact (right) side were not significantly different between wild-type and each of the three KO genotypes (p>0.05, Student’s t-test).