Figure 2.
Panels A and B are VBG tracings taken from a single subject during the same closed-loop study. Time zero is when glucagon was delivered. Insulin on board is noted by a solid curve. Blood glucose is noted by solid diamonds (panel A) or empty diamonds (panel B). In panel A, insulin on board was low (less than 4 U), blood glucose remained stable, and hypoglycemia did not occur. In panel B, insulin on board was higher (above 6 U) and hypoglycemia did occur (as indicated by an arrow).