Table 4.
Brain regions with significant differences between placebo and a high dose of alcohol. Results are presented within voxels that survive an omnibus F-test for dose effects (q<.05 FDR). All results in this contrast surpass p<.001 uncorrected, activation extent 20 contiguous voxel thresholds appropriate to these planned comparisons. Brain regions are reported using reference to stereotactic MNI atlas labeling, along with peak t score for each regional activation difference and its x, y, z coordinates.
| Regions | Hemisphere | Max T | X, Y, Z |
|---|---|---|---|
| PLACEBO MINUS HIGH DOSE | |||
| Superior frontal gyrus (SMA) | Midline | 6.05 | 6, 3, 66 |
| Left | 4.15 | -30, -9, 66 | |
| Right | 3.72 | 33, 3, 63 | |
| Medial frontal gyrus (pre-SMA) | Midline | 5.23 | 3, 12, 48 |
| Anterior cingulate gyrus (BA 32) | Midline | 5.07 | -3, 27, 27 |
| Anterior cingulate gyrus (BA 24) | Midline | 5.09 | -6, 36, 15 |
| Medial frontal gyrus (dorsomedial) | Midline | 5.65 | -6, 54, 21 |
| Middle frontal gyrus (lat orbitofrontal) | Left | 4.68 | -39, 30, -6 |
| Right | 4.51 | 51, 24, -3 | |
| Insula | Left | 4.94 | -42, 12, -12 |
| Right | 5.35 | 39, 9, -9 | |
| Sensoriomotor cortex | Left | 4.70 | -45, -9, 57 |
| Left | 5.14 | -54, -15, 24 | |
| Precentral gyrus | Right | 4.04 | 45, 0, 57 |
| Superior temporal gyrus | Left | 5.75 | -63, -39, 21 |
| Left | 3.70 | -48, -60, 12 | |
| Right | 4.20 | 51, -27, -12 | |
| Right | 4.56 | 51, -54, 9 | |
| Posterior cingulate gyrus | Left | 3.67 | -12, -69, 9 |
| Right | 4.38 | 18, -69, 9 | |
| Precuneus | Midline | 4.45 | 9, -78, 51 |
| Thalamus | Left | 4.46 | -15, -15, 3 |
| Left | 4.61 | -6, -21, 9 | |
| Right | 4.59 | 18, -12, 6 | |
| Cerebellum (vermis) | Midline | 3.27 | 0, -75, -9 |
| Brainstem | 4.24 | 3, -15, -15 | |
| HIGH DOSE MINUS PLACEBO | |||
| No statistically significant findings. | |||