Table 5.

Brain regions with significant differences between moderate and high doses of alcohol. Results are presented within voxels that survive an omnibus F-test for dose effects (q<.05 FDR). All results in this contrast surpass p<.001 uncorrected, activation extent 20 contiguous voxel thresholds appropriate to these planned comparisons. Brain regions are reported using reference to stereotactic MNI atlas labeling, along with peak t score for each regional activation difference and its x, y, z coordinates.

Regions	Hemisphere	Max t	x, y, z
MODERATE MINUS HIGH DOSE
Superior frontal gyrus (SMA)	Midline	3.84	6, 12, 63
Superior/middle frontal gyrus (BA 10)	Left	5.77	-27, 45, 24
Middle frontal gyrus (BA 10)	Right	4.75	36, 45, 12
Medial frontal gyrus (pre-SMA)	Midline	3.82	9, 24, 48
Anterior cingulate gyrus (BA 32)	Midline	4.50	0, 30, 27
Cingulate gyrus (mid)	Midline	3.78	0, -12, 33
Insula	Left	4.46	-36, 9, 3
	Right	4.55	42, 18, 0
Sensoriomotor cortex	Left	4.84	-33, -24, 63
Superior temporal gyrus	Left	4.35	-57, -18, 15
	Left	4.54	-57, -30, 21
	Right	3.98	60, -42, 24
HIGH MINUS MODERATE DOSE
No statistically significant findings.