Table 2.
Replication of secondary SNPs in WGHS by BP trait
| Trait | SNP | Chromosome (Position, NCBI 36.3) | Nearest Gene | Allele (coded/other) | Freq. coded allele | Prior study* | WGHS | WGHS (non-primary trait)‡ |
|---|---|---|---|---|---|---|---|---|
| p-value | p-value† | p-value† | ||||||
| SBP | rs11014166 | 10 (18,748,804) | CACNB2 | A/T | 0.65 | 2.1E-06 | 3.2E-05 | 2.2E-06 |
| rs880315 | 1 (10,719,453) | CASZ1 | C/T | 0.35 | 2.1E-07 | 7.0E-04 | 7.0E-03 | |
| rs448378 | 3 (170,583,593) | MDS1 | A/G | 0.53 | 1.3E-06 | 3.4E-03 | 3.7E-02 | |
| rs1910252 | 8 (49,569,915) | EFCAB1 | C/T | 0.83 | 1.7E-06 | 3.0E-02 | 2.4E-01 | |
| rs2736376 | 8 (11,155,175) | MTMR9 | C/G | 0.13 | 1.9E-06 | 2.2E-01 | 3.3E-01 | |
| rs2092201 | 22 (24,910,475) | SEZ6L | C/T | 0.96 | 2.6E-05 | 2.3E-01 | 4.2E-01 | |
| rs7571613 | 2 (190,513,907) | PMS1 | A/G | 0.82 | 7.2E-07 | 3.4E-01 | 4.4E-01 | |
| rs6749447 | 2 (168,749,632) | STK39 | G/T | 0.27 | 1.6E-07 | 3.8E-01 | 1.5E-01 | |
| DBP | rs11024074 | 11 (16,873,795) | PLEKHA7 | C/T | 0.30 | 2.8E-07 | 3.4E-04 | 4.4E-03 |
| rs7016759 | 8 (49,574,969) | EFCAB1 | C/T | 0.17 | 1.9E-06 | 2.5E-01 | 3.9E-02 | |
| rs13423988 | 2 (68,764,770) | GPR73-ARGHGAP25 | C/T | 0.83 | 1.1E-06 | 3.9E-01 | 4.2E-01 | |
| rs13401889 | 2 (190,618,804) | MSTN | C/T | 0.22 | 9.7E-07 | 4.0E-01 | 4.1E-01 | |
| rs11646213 | 16 (66,940,701) | CDH13 | A/T | 0.41 | 5.6E-05 | 3.2E-01 | 2.8E-01 |
*
Prior study is CHARGE (Levy et al [7]), except for STK39 (Wang et al [18]) and CDH13 (Org et al [19])
†
One-tailed p-value, a priori significance at P < 1.2 × 10−3 for primary trait, and P < 5.8 × 10−4 for the non-primary trait (met when indicated in bold face font)
‡
Non-primary trait is DBP if the association was first reported with SBP in previous studies, and SBP if previous association was with DBP.