Table 4.
Meta-analysis of WGHS and CHARGE or Global BPgen results*
| Trait | SNP | Nearest gene(s) | Allele (coded/other) | Freq. coded allele | p-value* | |
|---|---|---|---|---|---|---|
| Primary SNPs | SBP | rs3184504 | SH2B3 | C/T | 0.51 | 1.9E-11 |
| rs2681492 | ATP2B1 | C/T | 0.19 | 4.9E-15 | ||
| rs17367504 | MTHFR | A/G | 0.84 | 1.2E-09† | ||
| rs11191548 | NT5C2;CYP17A1 | C/T | 0.09 | 1.1E-09† | ||
| rs381815 | PLEKHA7 | C/T | 0.73 | 1.1E-08 | ||
| rs1004467 | CYP17A1 | A/G | 0.90 | 1.1E-07 | ||
| rs12946454 | ACBD4 | A/T | 0.74 | 4.4E-04† | ||
| DBP | rs11014166 | CACNB2 | A/T | 0.65 | 9.7E-12 | |
| rs2681472 | ATP2B1 | A/G | 0.83 | 7.0E-13 | ||
| rs1378942 | CSK;CYP1A2 | A/C | 0.66 | 3.5E-11† | ||
| rs1530440 | c10orf107 | C/T | 0.81 | 9.6E-10† | ||
| rs653178 | ATXN2;SH2B3 | C/T | 0.49 | 1.2E-09† | ||
| rs3184504 | SH2B3 | C/T | 0.51 | 5.6E-11 | ||
| rs6495122 | CSK-ULK3 | A/C | 0.43 | 2.2E-09 | ||
| rs16948048 | ZNF652 | A/G | 0.63 | 4.5E-08† | ||
| rs2384550 | TBX3-TBX5 | A/G | 0.35 | 1.3E-07 | ||
| rs16998073 | FGF5 | A/T | 0.76 | 2.1E-07† | ||
| rs9815354 | ULK4 | A/G | 0.17 | 3.7E-05 | ||
| Secondary SNPs | SBP | rs11014166 | CACNB2 | A/T | 0.65 | 4.6E-10 |
| rs880315 | CASZ1 | C/T | 0.35 | 5.2E-09 | ||
| rs448378 | MDS1 | A/G | 0.53 | 9.1E-08 | ||
| rs1910252 | EFCAB1 | C/T | 0.83 | 2.6E-06 | ||
| rs2736376 | MTMR9 | C/G | 0.13 | 1.2E-04 | ||
| rs2092201 | SEZ6L | C/T | 0.96 | 6.7E-04 | ||
| rs7571613 | PMS1 | A/G | 0.82 | 2.3E-04 | ||
| DBP | rs11024074 | PLEKHA7 | C/T | 0.30 | 1.1E-09 | |
| rs7016759 | EFCAB1 | C/T | 0.17 | 8.9E-05 | ||
| rs13423988 | GPR73-ARGHGAP25 | C/T | 0.83 | 8.1E-04 | ||
| rs13401889 | MSTN | C/T | 0.22 | 8.7E-04 | ||
| eSNPs | SBP | rs7537765 | CLCN6;MTHFR | A/G | 0.84 | 2.6E-09 |
| rs249209 | ANKRD34B | G/T | 0.41 | 5.0E-03 | ||
| rs525381 | KDM5A;SLC6A13 | A/G | 0.28 | 2.5E-05 | ||
| rs7571613 | MSTN | A/G | 0.82 | 2.3E-04 | ||
| rs4572871 | SEC31A;near SCD5 | A/G | 0.21 | 2.5E-07 | ||
| rs2898290 | BLK;GATA4 | C/T | 0.53 | 3.2E-08 | ||
| DBP | rs739496 | SH2B3;ATXN2 | A/G | 0.79 | 1.2E-06 | |
| rs6495126 | MPI;SCAMP2;ULK3 | A/G | 0.30 | 3.4E-09 | ||
| rs1384883 | LRRIQ3 | C/T | 0.46 | 1.2E-03 | ||
| rs12466395 | PMS1 | A/G | 0.22 | 2.0E-04 | ||
| rs2272007 | ULK4 | C/T | 0.83 | 3.7E-05 | ||
| rs6601414 | MSRA | A/G | 0.46 | 2.0E-06 |
Bold face font indicates genome-wide significance met at P < 5.0 × 10−8
*
Of note, CDH13 was not included in the meta-analysis, as the previous report used a dominant, rather than additive genetic model [18]. Similarly, STK39 was not included, because the beta-coefficients and standard errors were not available from the previous study [19]
†
Meta-analysis combines CHARGE and WGHS, unless indicated by footnote, in which case the analysis combines Global BPgen and WGHS results