Skip to main content
. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: J Mol Cell Cardiol. 2010 Jul 23;49(4):587–597. doi: 10.1016/j.yjmcc.2010.07.010

Figure 7.

Figure 7

AMD3100 blockade of SDF-1α-CXCR4 signaling attenuates survival signaling while increasing proliferative signaling. (A) The effect of AMD blockade on CXCR4 signaling was assessed by Western analysis in mice treated with Vehicle or AMD with ligation or sham surgery 48 hr after surgery. Summarized data of normalized Western analysis is as follows: (B) p-AKT levels are attenuated in AMD3100-treated infarcted hearts. (C) GSK-3β pY216 is attenuated in AMD3100-treated infarcted hearts. (D) GSK-3β pS9 is insignificantly increased in AMD3100-treated hearts. (E) Cyclin D1 is significantly increased in AMD3100-treated infarcted hearts. (F) p-Cyclin D1 levels are decreased in AMD3100-treated infarcted mice. (G) Pin1 levels are increased in AMD3100-treated infarcted mice. Values are mean ± SEM (n = 4). *P<0.05 vs Vehicle Ligation; †P<0.05 vs AMD Sham.