Table 2.
Preterm delivery by genotype among non-Hispanic white and African-American women in the POUCH subcohort
| Non-Hispanic White N=560 |
African American N=447 |
|||||
|---|---|---|---|---|---|---|
| Genotype | Term Deliveries N (weighted %) |
Preterm Deliveries N (weighted %) |
OR (95% CI) a | Term Deliveries N (weighted %) |
Preterm Deliveries N (weighted %) |
OR (95% CI) a |
| TNF-α −G238A | ||||||
| Common allele | 372 (90.6%) | 134 (9.4%) | 341 (86.1%) | 73 (13.9%) | ||
| Rare allele | 39 (90.3%) | 15 (9.7%) | 1.0 (0.5, 1.9) | 25 (79.5%) | 8 (20.5%) | 1.6 (0.7, 3.4) |
| TNF-α −G308A | ||||||
| Common allele | 274 (89.8%) | 108 (10.2%) | 274 (85.1 %) | 64 (14.9%) | ||
| Rare allele | 137 (92.2%) | 41 (7.8%) | 0.7 (0.5, 1.0) | 92 (87.3%) | 17 (12.7%) | 0.8 (0.5, 1.4) |
| IL-1β +C3954Tb | ||||||
| Common allele | 248 (90.5%) | 89 (9.5%) | 268 (84.0 %) | 66 (16.0%) | ||
| Rare allele | 162 (90.8%) | 59 (9.2%) | 1.0 (0.8, 1.5) | 98 (90.3%) | 15 (9.7%) | 0.8 (0.4, 1.4) |
a
OR= Odds Ratio and 95 % confidence intervals for preterm birth was calculated by weighted logistic regression (with inverse probability weights to account for the POUCH Study sampling scheme). The heterozygote and homozygote rare allele genotypes were grouped together (rare allele) and compared to the homozygote non-rare allele genotype (common allele). The term common allele group was the reference category.
b
Two non-Hispanic white woman are missing IL-1β genotype.