. Author manuscript; available in PMC: 2010 Dec 21.

Published in final edited form as: Cell Cycle. 2009 Sep 29;8(17):2728–2732. doi: 10.4161/cc.8.17.9389

Table 1.

Similar functions for the FRK and PTK6 tyrosine kinases.

FUNCTION		OBSERVATION	REFERENCE
Differentiation	FRK	Neurite outgrowth; generation of insulin producing cells	20, 21
Differentiation	PTK6	Differentiation of keratinocytes and enterocytes	42, 43, 45
AKT Regulation	FRK	Decreased PI3K signaling; Upregulation of PTEN	35, 64
AKT Regulation	PTK6	Inhibition of AKT activation in vivo; Direct binding, phosphorylation, and inhibition of AKT in unstimulated cells	43, 47, 48
Nuclear Functions	FRK	Nuclear localization; Binding to RB	6, 7, 18
Nuclear Functions	PTK6	Nuclear localization; Binding and regulation of Sam68, SLM-1 and SLM-2	8–10, 49, 65
Growth Arrest	FRK	G1 arrest	6, 19, 27, 28
Growth Arrest	PTK6	Negative regulator of proliferation in normal intestine	43
Apoptosis	FRK	Sensitization of islet cells to cytokine-induced death	23, 25, 26
Apoptosis	PTK6	Sensitization of non-transformed cells to UV and serum starvation; DNA-damage-induced apoptosis in small intestine	46, 47