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. 2010 Dec 20;207(13):2817–2830. doi: 10.1084/jem.20100844

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© 2010 Takayama et al.

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Figure 1. — Four-factor human iPSCs are better than three-factor iPSCs for megakaryopoiesis, which is independent of hematopoietic colony potential. (A) Numbers of ESC- and iPSC-sac–like structures generated from 10⁵ cells (n = 3, means ± SEM from three independent experiments). (B) Numbers of CD34⁺ hematopoietic progenitors within ESC- or iPSC-sacs yielded from 10⁵ human ESCs or iPSCs (n = 3, means ± SEM). (C) Numbers of hematopoietic colonies derived from 10⁵ human ESCs or iPSCs within sacs (n = 3, means ± SEM). (D and E) Numbers of CD42b (GPIbα)⁺ MKs derived from 10⁵ hematopoietic progenitors within sacs on day 22 (D) and day 26 (E; n = 5, means ± SEM). (F) Representative flow cytometry dot plots for khES-3–, TkDN-4-M–, and TkDA3-4–derived MKs examined on day 24.