Fig. 5.
Cellular proliferation in distal crypts 72 h after AOM. Bar graphs summarize results for the proliferation index (percent cells BrdU positive) in the entire crypt (total), or in the basal, middle and apical portions of crypts in WT (black bars)and SDR rats (open bars) treated with AOM (black bars) or carrier alone (open bars). Results for a total of 10 crypts from three animals in each group are shown. Asterisks (*) indicate significant differences in the percent of cells labeled in the entire crypt or apical or middle compartments in WT rats treated with AOM (P < 0.05).