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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Dev Neurobiol. 2011 Jan 1;71(1):83–91. doi: 10.1002/dneu.20815

Figure 2. Cell-type specific actions of CCK in Hippocampal Microcircuits.

Figure 2

(a) CCK-expressing and PV-expressing basket cells provide the main source of perisomatic inhibition to the pyramidal cells. CCK strongly depolarizes the PV-expressing basket cells, but suppresses GABAergic transmission from the CCK-expressing basket cells (CCK effects are indicated by the direction of the red arrows) [Modified with permission of Neuron from Freund and Katona (2007)] (b) Sample trace from a PV-expressing basket cell shows the CCK-induced increase in firing. (c) CCK significantly inhibited the unitary IPSCs in pyramidal cells that were evoked by presynaptic CCK-expressing basket cells [Modified with permission of Nature Publishing Group from Földy et al. (2007)].