Table 3.
Parameter | Concentration (mean ± S.E.) in group† | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Control diet | Magnesium carbonate‐containing diet | Lanthanum carbonate‐containing diet | ||||||||||
1m → 3m | 1m → 6m | 1m → 3m | 1m → 4m | 1m → 5m | 1m → 6m | 3m → 6m | 1m → 3m | 1m → 4m | 1m → 5m | 1m → 6m | 3m → 6m | |
Calcium (mg/dL) | 11.06 ± 2.73 | 9.16 ± 1.45 | 95.41 ± 19.3† | 90.77 ± 15.74† | 115.42 ± 16.48† | 132.89 ± 16.13† | 119.04 ± 15.35† | 19.06 ± 6.09 | 10.13 ± 0.89 | 21.53 ± 5.51 | 6.86 ± 2.93 | 10.22 ± 2.90 |
Phosphorus (mg/dL) | 443.31 ± 118.42 | 334.78 ± 110.23 | 105.91 ± 24.13‡ | 19.77 ± 19.77† | 0.02 ± 0.02† | 1.26 ± 1.26† | 0 ± 0+ | 319.35 ± 136.3 | 370.94 ± 82.15 | 194.68 ± 56.75 | 165.93 ± 16.07 | 244.30 ± 86.43 |
Magnesium (mg/dL) | 28.49 ± 1.10 | 28.78 ± 0.44 | 30.83 ± 0.46‡ | 29.63 ± 0.57 | 30.73 ± 0.12† | 30.90 ± 0.16† | 30.64 ± 0.53‡ | ND | ND | ND | ND | ND |
*Abcc6−/− mice at 1 or 3 months of age were placed on different diets. Urine concentrations of calcium, phosphorus and magnesium were determined at 3, 4, 5 and 6 months of age.
†Statistical significance in comparison to the Abcc6 −/− mice on control diet is indicated: ‡ p < 0.05; † p < 0.01 (n = 5–9).
ND = not determined.