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Lymphocytes were preincubated in 1% BSA in RPMI (panel A) and 1% BSA in RPMI containing 10 μg CsA/mL (panel B) or 1 μg FK/mL (panel C) for 24 hours. The cellular uptake of [3H] CsA was then measured in the absence (○—○) and presence of equivalent amounts of FK (△—△) and cold CsA (▲—▲). ●—● indicates displacement of [3H] CsA in the presence of a 100-fold excess of cold CsA.
