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. Author manuscript; available in PMC: 2010 Dec 21.
Published in final edited form as: J Neurophysiol. 2003 Mar;89(3):1308–1316. doi: 10.1152/jn.00644.2002

FIG. 5.

FIG. 5

Group I and II mGluRs have opposite effects on holding current. A: group I drugs. Ai: agonist (S)-3,5-dihydroxyphenylglycine (DHPG, 100 μM, n = 5) shifts holding current in the negative direction. Aii: antagonist AIDA (1 mM, n = 5) shifts holding current in the positive direction. B: group II drugs. Bi: agonist DCG IV (1 μM, n = 7) shifts holding current in the positive direction. Bii: antagonist LY341495 (2 μM, n = 8) shifts holding current in the negative direction. All holding current measurements in A and B were made relative to pre-drug holding current.