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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Curr Opin Immunol. 2010 Nov 2;22(6):783–788. doi: 10.1016/j.coi.2010.10.005

Figure 1. Peanut activation of complement exacerbates anaphylaxis.

Figure 1

Peanut molecules activate complement, causing production of C3a, which acts through C3a receptors on mast cells, basophils and macrophages to induce production of PAF and histamine, which directly and indirectly increase vascular permeability and smooth muscle contractility.