Table 3.

Family-based association analysis in candidate regions identified by linkage scans

Radiation-induced gene expression phenotype	Time after irradiation (h)	Potential regulator	GO function	Linkage (P)	Chromosome	QTDT SNP ID	QTDT (P)
ARHGDIA	2	SERPINE2	Serine peptidase inhibitor	3.21 × 10−7	2	rs6734100	0.0002
HRAS	2	RB1	Transcription factor	5.40 × 10−6	13	rs198584	0.0033
JUN	2	LCP2	Transmembrane receptor signalling pathway	1.46 × 10−9	5	rs10068619	0.0213
BIRC4	2	CDK9	Cyclin-dependent kinase	6.80 × 10−6	9	rs1002095	0.0305
TNFSF9	2	CD44	Receptor	1.38 × 10−5	11	rs353615	0.0321
HMMR	2	CDC2	Cyclin-dependent kinase	1.10 × 10−6	10	rs1871445	0.0385
RFX3	2	HIVEP2	Regulation of transcription	6.00 × 10−7	6	rs533173	0.0442
TRAF4	6	FAS	Signal transduction	4.00 × 10−7	10	rs9658786	0.0044
TNFSF4	6	LTA4H	Zinc ion binding	3.38 × 10−7	12	rs7296106	0.0057
SPARC	6	VDR	Transcription factor activity	1.85 × 10−7	12	rs2254210	0.0077
RFX3	6	DYNC2LI1	Motor activity	4.00 × 10−7	2	rs2278356	0.01
NT5E	6	NDUFB6	Mitochondrial electron transport	5.48 × 10−9	9	rs628425	0.0179
FAS	6	SSB	mRNA binding	1.20 × 10−6	2	rs7589845	0.0215
FAS	6	UBA52	Ribosome/protein modification	1.13 × 10−8	19	rs2057649	0.0296