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Cyclosporine Pharmacokinetics
| Transplant Group | Cyclosporine Clearance Rate, mL/min* per Kilogram | Half-life, h | Volume of Distribution, L/kg* | Bioavailability, % |
|---|---|---|---|---|
| Pediatric renal (n = 7) | 11.8 (9.8–15.5) | 7.3 | 4.7 (3–7.4) | 31 |
| Pediatric liver (n = 7) | 8.4 (1.9–13.9) | … | … | <5–18 |
| Multivisceral† (n = 1) | 3.4 | 11.3 IV | 2.3 | 0 |
| 9.1 PO | … | 2 | ||
| 3.8 | 16.0 IV | 4.3 | … | |
| 13.6 PO | … | 8 | ||
Numbers in parentheses indicate range.
IV indicates intravenous; and PO, oral.
