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. Author manuscript; available in PMC: 2010 Dec 21.
Published in final edited form as: Biochem J. 2009 Dec 23;425(2):435–444. doi: 10.1042/BJ20091237

Figure 8. Conserved regions 4, 7 and 9 are highly active in Notch4-immortalized cells.

Figure 8

The 75 kb SOX10 gene including its exons (E1 to E4) and its upstream sequence are presented along with the nine MCSs which show high conservation among different species (top panel). The SOX10 MCSs inserted into the upstream of a minimal promoter-driven luciferase reporter were transfected along with the β-gal expression vector into Notch4-immortalized wild-type (open bars) or PBP-deficient cells (grey bars) (bottom panel). E1B represents the minimal promoter-driven luciferase reporter. Luciferase activity was normalized to β-gal activity.