Table 1.
Characteristics of TZD users and non-users.
| Study – 1 Adenoma anywhere in the colon |
Study – 2 Distal Adenoma |
|||
|---|---|---|---|---|
| Cases N=1296 |
Controls N=2952 |
Cases N=951 |
Controls N=8862 |
|
| Female (%) | 41 | 49 | 37 | 46 |
| Age (median years, IQR) | 71 (65-77) | 71 (64-77) | 67 (60-74) | 66 (60-73) |
| Race (%) | ||||
| White | 60 | 59 | 57 | 52 |
| Black | 14 | 12 | 12 | 16 |
| Hispanic | 12 | 12 | 12 | 13 |
| Asian | 10 | 11 | 14 | 14 |
| Other | 2 | 3 | 2 | 3 |
| Missing | 2 | 3 | 2 | 3 |
| BMI (%) | ||||
| 25 or less | 17 | 17 | 16 | 17 |
| >25 to 30 | 36 | 34 | 38 | 34 |
| >30 | 36 | 38 | 36 | 37 |
| Missing | 10 | 11 | 10 | 12 |
| Socioeconomic status (%) | ||||
| < median | 49 | 47 | 42 | 45 |
| ≥ the median | 49 | 50 | 55 | 52 |
| Missing | 3 | 3 | 2 | 3 |
| Diabetes duration (%) | ||||
| Less than 5 years | 26 | 30 | 34 | 33 |
| 5 to <10 years | 25 | 23 | 25 | 24 |
| 10 or more years | 39 | 40 | 32 | 35 |
| Missing | 10 | 8 | 9 | 9 |
| Concomitant medications* (%) | ||||
| NSAID | 12 | 17 | 11 | 15 |
| Aspirin | 2 | 2 | 1 | 1 |
| Proton pump inhibitor | 4 | 6 | 2 | 3 |
| Statin | 38 | 38 | 32 | 34 |
| Most recent lower endoscopy during 1995-1998 (%) | ||||
| Colonoscopy ≤ 3 years prior** | 5 | 5 | 1 | 1 |
| Sigmoidoscopy ≤ 3 years prior** | 5 | 5 | 1 | 3 |
| Colonoscopy > 3 years prior** | 19 | 19 | 3 | 3 |
| Sigmoidoscopy >3 years prior** | 19 | 22 | 11 | 16 |
| None | 53 | 49 | 84 | 78 |
| Lower endoscopy with polypectomy 1995-1998 (%) | 18 | 16 | 5 | 4 |
*
At least one year of cumulative use and use within 1 year of the index date
**
Prior to index date