Table 4a. Logistic regression analysis with HbA1c quartile as exposure in two-year intervals (Study 1 – Adenoma anywhere in colon)*.
| HbA1c Quartile | Prior Year 1-2 | Prior Year 3-4 | Prior Year 5-6 | Prior Year 7-8 | Prior Year 9-10 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Any adenoma Adjusted OR** (95% CI) | Advanced adenoma Adjusted OR** (95% CI) | Any adenoma Adjusted OR** (95% CI) | Advanced adenoma Adjusted OR** (95% CI) | Any adenoma Adjusted OR** (95% CI) | Advanced adenoma Adjusted OR** (95% CI) | Any adenoma Adjusted OR** (95% CI) | Advanced adenoma Adjusted OR** (95% CI) | Any adenoma Adjusted OR** (95% CI) | Advanced adenoma Adjusted OR** (95% CI) | |
| 3.40-6.90 | Reference n=403 |
Reference n=148 |
Reference n=291 |
Reference n=110 |
Reference n=224 |
Reference n=86 |
Reference n=131 |
Reference n=57 |
Reference n=61 |
Reference n=24 |
| 6.91-7.78 | 1.0 (0.9-1.2) n=349 |
1.2 (0.9-1.6) n=141 |
1.1 (0.9-1.4) n=301 |
1.3 (0.9-1.7) n=126 |
1.0 (0.8-1.3) n=246 |
1.0 (0.7-1.5) n=97 |
1.2 (0.9-1.7) n=126 |
0.9 (0.6-1.5) n=40 |
0.9 (0.6-1.4) n=58 |
0.9 (0.5-1.8) n=24 |
| 7.79-8.90 | 1.0 (0.8-1.2) n=276 |
1.1 (0.8-1.5) n=102 |
1.0 (0.8-1.2) n=283 |
0.9 (0.6-1.3) n=96 |
0.8 (0.7-1.1) n=245 |
0.8 (0.6-1.2) n=93 |
1.0 (0.7-1.4) n=141 |
1.1 (0.7-1.7) n=61 |
1.0 (0.6-1.5) n=66 |
0.8 (0.4-1.5) n=20 |
| 8.91-17.9 | 1.1 (0.9-1.4) n=219 |
1.1 (0.7-1.6) n=71 |
1.2 (0.9-1.5) n=291 |
1.2 (0.8-1.7) n=103 |
1.0 (0.7-1.3) n=293 |
0.9 (0.6-1.3) n=95 |
1.0 (0.8-1.4) n=191 |
1.0 (0.6-1.6) n=74 |
1.1 (0.7-1.7) n=123 |
1.3 (0.7-2.4) n=55 |
| Missing | 0.9 (0.6-1.3) n=49 |
0.8 (0.4-1.4) n=16 |
1.3 (1.0-1.7)† n=130 |
1.2 (0.8-1.8) n=43 |
1.0 (0.8-1.3) n=288 |
1.1 (0.7-1.5) n=107 |
1.1 (0.8-1.5) n=707 |
1.0 (0.7-1.6) n=246 |
0.8 (0.5-1.1) n=988 |
0.9 (0.5-1.5) n=355 |
| Table 4b. Logistic regression analysis with HbA1c quartile as exposure in two-year intervals (Study 2 - Distal Adenoma)* | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HbA1c Quartile | Prior Year 1-2 | Prior Year 3-4 | Prior Year 5-6 | Prior Year 7-8 | Prior Year 9-10 | |||||
| Any adenoma Adjusted OR** (95% CI) | Advanced adenoma Adjusted OR** (95% CI) | Any adenoma Adjusted OR** (95% CI) | Advanced adenoma Adjusted OR** (95% CI) | Any adenoma Adjusted OR** (95% CI) | Advanced adenoma Adjusted OR** (95% CI) | Any adenoma Adjusted OR** (95% CI) | Advanced adenoma Adjusted OR** (95% CI) | Any adenoma Adjusted OR** (95% CI) | Advanced adenoma Adjusted OR** (95% CI) | |
| 4.46-7.00 | Reference n=248 |
Reference n=94 |
Reference n=224 |
Reference n=67 |
Reference n=156 |
Reference n=46 |
Reference n=86 |
Reference n=24 |
Reference n=35 |
Reference n=11 |
| 7.01-7.87 | 1.0 (0.8-1.3) n=238 |
0.6 (0.4-0.9)† n=59 |
1.0 (0.8-1.2) n=199 |
1.1 (0.7-1.6) n=62 |
1.1 (0.8-1.4) n=141 |
1.4 (0.9-2.1) n=51 |
1.0 (0.7-1.4) n=69 |
1.1 (0.6-2.0) n=22 |
0.9 (0.5-1.6) n=27 |
0.4 (0.1-1.3) n=4 |
| 7.88-9.10 | 1.0 (0.8-1.3) n=225 |
0.7 (0.5-1.1) n=63 |
0.9 (0.7-1.1) n=211 |
1.1 (0.7-1.6) n=66 |
1.3 (1.0-1.7)† n=212 |
1.3 (0.8-2.1) n=60 |
1.1 (0.7-1.5) n=90 |
1.1 (0.6-2.1) n=28 |
0.8 (0.5-1.3) n=38 |
1.1 (0.5-2.5) n=17 |
| 9.10-17.5 | 1.1 (0.9-1.4) n=185 |
0.9 (0.6-1.4) n=55 |
1.0 (0.8-1.3) n=211 |
1.1 (0.7-1.7) n=58 |
1.0 (0.8-1.4) n=175 |
1.1 (0.7-1.8) n=52 |
1.1 (0.8-1.6) n=114 |
1.3 (0.7-2.3) n=32 |
0.9 (0.6-1.6) n=40 |
1.1 (0.5-2.7) n=15 |
| Missing | 1.5 (1.1-2.1)† n=55 |
1.3 (0.7-2.2) n=18 |
1.0 (0.7-1.3) n=106 |
1.2 (0.8-1.9) n=36 |
1.2 (0.9-1.5) n=267 |
1.2 (0.8-1.9) n=80 |
0.9 (0.7-1.3) n=592 |
1.5 (0.9-2.6) n=183 |
1.1 (0.7-1.8) n=811 |
0.9 (0.4-1.9) n=242 |
*
Patients without any adenoma as controls
**
Adjusted for sex, age, ethnicity, BMI, income status, year of large bowel endoscopy, duration of diabetes, NSAID use, aspirin use, statin use and use of acid suppressive medications.
†
P<0.05