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. Author manuscript; available in PMC: 2011 Dec 15.

Published in final edited form as: Anal Chem. 2010 Nov 19;82(24):10172–10178. doi: 10.1021/ac102317a

LC-MS SRM chromatograms and formation rate plot for styrene oxide DNA adducts using PDDA/DNA bioreactors with 5 mM styrene oxide. (A) βN⁷-SO-guanine with mass transition m/z 272>152 (t_R = 9.54 min), 5 min reaction; (B) αN³-SO-adenine with mass transition m/z 256>136 (t_R = 9.12 min), 5 min reaction. (C) Influence of reaction time on βN⁷-SO-guanine (■) and αN³-SO-adenine (), area ratio to internal standard 7-methylguanosine (m/z 298>166).

Inline graphic — LC-MS SRM chromatograms and formation rate plot for styrene oxide DNA adducts using PDDA/DNA bioreactors with 5 mM styrene oxide. (A) βN⁷-SO-guanine with mass transition m/z 272>152 (t_R = 9.54 min), 5 min reaction; (B) αN³-SO-adenine with mass transition m/z 256>136 (t_R = 9.12 min), 5 min reaction. (C) Influence of reaction time on βN⁷-SO-guanine (■) and αN³-SO-adenine (), area ratio to internal standard 7-methylguanosine (m/z 298>166).