Figure 8).

A The line graph shows the effect of vitamin (Vit) B₆, Vit E, Vit C and lipoic acid supplemented in the diet on systolic blood pressure in spontaneously hypertensive rats (SHRs). Starting at 12 weeks of age, animals were divided into six groups of six animals each. For nine weeks, animals in the Wistar-Kyoto (WKY)-control and SHR-control group were given a normal diet; the SHR-Vit B₆ group was given a diet supplemented with 20 mg Vit B₆; the SHR-Vit C group was given a diet supplemented with 100 mg Vit C; the SHR-Vit E group was given a diet supplemented with 3.4 mg Vit E; and the SHR-lipoic acid group was given a diet supplemented with 50 mg of lipoic acid per 100 g of diet. All animals were given normal drinking water. Values are given as the mean of the six animals in each group. SDs did not vary more than 6 mmHg in each case. Values are significantly different (P<0.05) from one to nine weeks in the SHR-control group compared with other groups of the same age. B The bar graph shows the effect of an antioxidant-supplemented diet on kidney and aortic aldehyde conjugates in SHRs. The experimental groups and treatment period were the same as in A. Data are presented as mean ± SD of the six animals in each group at the completion of the study at 21 weeks of age. *Values are significantly different (P<0.05) from other groups. QS Quinine sulphate. Data from references 27 to 30