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Mean ± SE observed A1C values during the 2-year intervention period in patients randomized to treatment with either NPH insulin (black symbols) or insulin aspart (open symbols) in combination with placebo (A, P < 0.001), metformin (B, P = 0.15), rosiglitazone (C, P < 0.02), or metformin and rosiglitazone (D, P = 0.15).
