Table 1.
Clinical, hematological, and biochemical characteristics of nondiabetic control subjects and pretreatment and posttreatment data for subjects with type 2 diabetes
| Parameters | Nondiabetic subjects | Diabetic subjects pretreatment | Diabetic subjects posttreatment | P |
|---|---|---|---|---|
| Age (years) | 50.4 ± 3.8 | 51.0 ± 3.1 | 51.0 ± 3.1 | NS |
| BMI (kg/m2) | 28.0 ± 0.9 | 30.4 ± 0.7 | 30.0 ± 0.9 | NS |
| Hemoglobin (g/l) | 14.2 ± 1.8 | 13.7 ± 1.4 | 13.7 ± 1.2 | NS |
| Fasting plasma glucose (mmol/l) | 5.0 ± 0.1 | 10.7 ± 0.5* | 10.6 ± 0.4 | <0.001* |
| A1C (%) | 5.5 ± 0.1 | 9.1 ± 0.2* | 9.0 ± 0.2 | <0.001* |
| Blood urea nitrogen (mmol/l) | 5.3 ± 0.3 | 5.4 ± 0.6 | 5.4 ± 0.4 | NS |
| Creatinine (μmol/l) | 88.4 ± 3.4 | 79.6 ± 4.2 | 79.6 ± 3.8 | NS |
| Alanine aminotransferase (U/l) | 20.4 ± 1.2 | 23.8 ± 5.0 | 24.4 ± 4.4 | NS |
| Aspartate aminotransferase (U/l) | 17.6 ± 1.4 | 18.2 ± 2.4 | 17.9 ± 2.6 | NS |
| Glutamate (mmol/l) | 530.1 ± 88.3 | 451.5 ± 120.7 | 482.4 ± 98.2 | NS |
| Cysteine (μmol/l) | 25.2 ± 1.5 | 17.8 ± 1.5* | 25.5 ± 1.9† | <0.01* |
| <0.05† | ||||
| Glycine (μmol/l) | 514.7 ± 33.1 | 403.2 ± 18.2* | 521.6 ± 19.4† | <0.01* |
| <0.01† | ||||
| DROMs (UCarr) | 286 ± 10 | 403 ± 11* | 359 ± 10†‡ | <0.001* |
| <0.05† | ||||
| <0.01‡ | ||||
| Lipid peroxide (μmol/l) | 2.6 ± 0.4 | 10.8 ± 1.2* | 6.2 ± 0.9†‡ | <0.001* |
| <0.01† | ||||
| <0.05‡ |
*Nondiabetic control subjects versus diabetic subjects: pre-treatment.
†Diabetic subjects: pretreatment versus posttreatment.
‡Diabetic subjects: posttreatment versus nondiabtic control subjects.