Table 2.
Demographic, epidemiologic, and clinical characteristics
| Case no. | Age/sex | Geographic site lesion acquired | Location of lesion | Lesion appearance | No. of lesions | Baseline size of lesion (cm2)* | Size of lesion at 1 month (cm2)* | Duration of lesion (months) | Prior treatment | Treatment | Treatment side effects | Treatment course completed | Cure | Follow-up (months) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| L. infantum chagasi | ||||||||||||||
| 1 | 60/M | Spain | Right ear | Diffuse, inflammatory, non-ulcerated | Single | 8.4 | 5.67 | 11 | No | Miltefosine | Mild loose stools | Yes | Yes | 12 |
| 2 | 25/F | El Salvador | Left cheek | Nodular | Single | 4.14 | 2.25 | 36 | No | Liposomal amphotericin B | Nephrotoxicity | No | No | 11 |
| Miltefosine | Motion sickness | No | Yes | 39 | ||||||||||
| 3 | 7/M | El Salvador | Face | Nodular | Multiple | 1.06 | 0.42 | 24 | No | Liposomal amphotericin B | None | Yes | Yes | 12 |
| L. V. panamensis | ||||||||||||||
| 4 | 29/F | Costa Rica | Left arm | Ulcerative | Single | 15.21 | 10.5 | 4 | No | Liposomal amphotericin B | Flushing, shortness of breath, chest pain | No | – | – |
| Ketoconazole | None | Yes | Yes | 12 | ||||||||||
| 5 | 67/F | Panama | Right and left shoulders | Dry, crusted | Multiple | 13.73 | 0.34 | 8 | No | Ketoconazole | None | Yes | Yes | 8 |
| 6 | 65/M | Panama | Right knee, elbow, shoulder | Ulcerated, nodular | Multiple | 14.25 | 0 | 8 | No | Ketoconazole | Hepatitis | No | Yes | 8 |
| L. V. braziliensis | ||||||||||||||
| 7 | 55/M | Ecuador | Right arm | Ulcerated | Single | 0.16 | 0 | 1 | Yes | Liposomal amphotericin B | Nephrotoxicity | Yes | Yes | 12 |
| 8 | 37/F | Costa Rica | Left arm, right leg | Dry, crusted | Multiple | 6.13 | 2.69 | 1 | No | Liposomal amphotericin B | Nausea, fleeting rash | Yes | Yes | 36 |
| 9 | 40/F | Costa Rica | Left arm, right leg | Ulcerated, nodular | Multiple | 11.12 | 7.89 | 1 | No | Liposomal amphotericin B | Nausea, dizziness | Yes | Yes | 36 |
| L. tropica | ||||||||||||||
| 10 | 6/M | Afghanistan | Right cheek, left wrist | Papules | Multiple | 0.04 | 0 | 9 | Yes | Liposomal amphotericin B | Hypokalemia, nephrotoxicity | No | No† | 3 |
M = male; F = female; No. = number.
*
Measurement of lesion size was performed to the nearest centimeter of the long and short axes of each lesion by one observer and calculated by multiplying the lengths of the axes (assuming the lesion was rectangular). For multiple lesions, the sum of the areas for each lesion was calculated to provide a total surface area. For case 1, the lesion was infiltrative and did not have discrete borders. An approximate measurement is provided for this lesion.
†
Case 10 was lost to follow-up after 3 months. Therefore, clinical response to therapy could not be assessed after this time point.