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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Med Res Rev. 2011 Jan;31(1):93–117. doi: 10.1002/med.20177

Table I.

Clinical indications
of methylene blue
Dose References
Methemoglobinemias 1-2 mg/kg I.V. Bradberry, 2003
Ifosfamide-induced encephalopathy 50 mg IV every four
hour till symptoms
resolve
Küpfer et al., 1994;
Alici-Evcimen and Breitbart, 2007
Treatment of vasoplegic syndrome 2 mg/kg, 20-min
infusion time
Shanmugam, 2005
Parathyroid imaging 3-7.5 mg/kg I.V. Dudley et al., 1971;
Gordon et al., 1975;
Rowley et al., 2009
Sentinel lymph node biopsy Local application of
1-5 ml of 1% MB
Varghese et al., 2007
Treatment of malaria 10 mg/kg twice
a day orally
Coulibaly et al., 2009