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. Author manuscript; available in PMC: 2010 Dec 21.
Published in final edited form as: Immunobiology. 2009 May 20;215(8):598–605. doi: 10.1016/j.imbio.2009.04.001

Fig. 1.

Fig. 1

Natural and synthetic cannabinoids induce apoptosis in T cells. THC (20 μM) and JWH-015 (5, 10, 20 μM) induce apoptosis in T cells through ligation of CB2 receptor. JWH-015 activates both the intrinsic pathway and the extrinsic pathway, and THC downregulates Bcl-2 mRNA and induces caspase 1 activity. It is not known if CBD and Aja exert their effects through receptor-dependent pathways; however, one report has shown that CBD may mediate its effect through CB2 receptor (McKallip et al. 2006).