Table 2.
Effect of high grade (Gleason 8-10) on recurrence post prostatectomy
| Gl 8-10 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Study | # pts | PSA Failure | Months Med f/u (mean) | modifiers | Failure rate | 5 yr DFS | 7 yr DFS | 10 yr DFS |
| Han21 | 2091 | ≥ 0.2 | 71 | PSA 0-4 | ||||
| NS | ECE+ | 44% | 21% | |||||
| ECE- | 78% | 63% | ||||||
| PSA 4-10 | ||||||||
| ECE+ | 37% | 15% | ||||||
| EPE- | 75% | 57% | ||||||
| PSA 10.1-20 | ||||||||
| EPE+ | 31% | 11% | ||||||
| EPE- | 71% | 52% | ||||||
| PSA>20 | ||||||||
| EPE+ | 25% | 7% | ||||||
| EPE- | 66% | -- | ||||||
| Han22 | 160 | >0.2 | (76) | 44% | 29% | 15% | ||
| Roehl24 | 237 | ≥ 0.3 | (65) | 32% | ||||
| Mian28 | 188 | ≥ 0.1 | 60 | 71% | 56% | |||
| 50 | EPE+mar- | 84% | ||||||
| 16 | EPE+mar+ | 62% | ||||||
| Stephenson30 | 118 | ≥ 0.2 x2 | 38 | Mar+ | 17% | |||
| 200 | Mar- | 45% | ||||||
| Hull 32 | 38 | 0.4 | 47 | 49% | 41% | |||
| Frazier 43 | 51 | >0.5 | NS | 69% | ||||
| Epstein 44 | 41 | >0.2 | 72(78) | 59%* | 35% | |||
| Ohori45 | 268# | >0.4 | 30 | 55% | ||||
| Rodriquez47 | 180 | ≥ 0.2 | 21 | 51% | 40% | |||
| Grossfeld 48 | 77 | ≥ 0.2x2 | 37 | PSA<10 | 47% | -- | ||
| 37 | PSA>10 | 19% | -- | |||||
DFS= disease free survival based on PSA
Mar+ is margin positive; Mar- is margin negative; EPE+ is extraprostatic extension present; EPE- is extraprostatic extension absent; foc is focal; Ext is extensive; Est is established; Gl is Gleason score. #Gleason 7-10; * 4 years