Fig. 4.

Relative I/O of each cell line in response to vincristine, melphalan, etoposide, and rapamycin. Values close to 0 are consistent with cytostasis, values close to 1 indicate no treatment effect, and values close to -1 indicate primarily cytotoxicity. In using results obtained for the Relative I/O metric, we categorize results, for example, a value of < −0.8 would indicate a strong cytotoxic effect, while a value of > 0.8 would indicate no treatment effect. Values between −0.2 and +0.2 likely indicate a primarily cytostatic effect. Other values could be assigned to intermediate categories (for example, modest cytostasis for 0.2 to 0.8 or moderate cytotoxicity for −0.2 to −0.8).