Table 1.
Clinical and demographic characteristics of the study population
| Siblings (N=319) | AML (N=281) | ALL (N=120) | AML & ALL (401) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | p-value* | N | % | p-value* | N | % | p-value* | |
| Institution | <0.001 | 0.061 | <0.001 | ||||||||
| City of Hope | 115 | (36.1) | 149 | (53.0) | 55 | (45.8) | 204 | (50.9) | |||
| University of Minnesota | 204 | (63.9) | 132 | (47.0) | 65 | (54.2) | 197 | (49.1) | |||
| Sex | 0.003 | <0.001 | <0.001 | ||||||||
| Female | 203 | (63.6) | 145 | (51.6) | 41 | (34.2) | 186 | (46.4) | |||
| Male | 116 | (36.4) | 136 | (48.4) | 79 | (65.8) | 215 | (53.6) | |||
| Race/ethnicity | <0.001 | <0.001 | <0.001 | ||||||||
| White | 296 | (92.8) | 230 | (81.9) | 89 | (74.2) | 319 | (79.6) | |||
| Black | 4 | (1.3) | 1 | (0.4) | 4 | (3.3) | 5 | (1.2) | |||
| Native American | 2 | (0.6) | 1 | (0.4) | 1 | (0.8) | 2 | (0.5) | |||
| Asian | 3 | (0.9) | 16 | (5.7) | 8 | (6.7) | 24 | (6.0) | |||
| Hispanic | 10 | (3.1) | 33 | (11.7) | 18 | (15.0) | 51 | (12.7) | |||
| Other | 3 | (0.9) | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | |||
| Transplant type | |||||||||||
| Related sibling | NA | 157 | (55.9) | 82 | (68.3) | 239 | (59.6) | ||||
| Autologous | NA | 93 | (33.1) | 20 | (16.7) | 113 | (28.2) | ||||
| Unrelated | NA | 29 | (10.3) | 17 | (14.2) | 46 | (11.5) | ||||
| Matched related | NA | 2 | (0.7) | 0 | (0.0) | 2 | (0.5) | ||||
| Syngeneic | NA | 0 | (0.0) | 1 | (0.8) | 1 | (0.2) | ||||
| Stem cell source | |||||||||||
| BM | NA | 220 | (78.3) | 114 | (95.0) | 334 | (83.3) | ||||
| PBSC | NA | 43 | (15.3) | 3 | (2.5) | 46 | (11.5) | ||||
| BM & PBSC | NA | 14 | (5.0) | 1 | (0.8) | 15 | (3.7) | ||||
| Cord Blood | NA | 3 | (1.1) | 0 | (0.0) | 3 | (0.7) | ||||
| Conditioning regimen | |||||||||||
| Chemotherapy | 40 | (14.2) | 0 | (0.0) | 40 | (10.0) | |||||
| Chemotherapy & Radiation | 241 | (85.8) | 120 | (100.0) | 361 | (90.0) | |||||
| Chronic graft versus host disease † | |||||||||||
| Yes | 88 | (46.8) | 39 | (39.4) | 127 | (44.3) | |||||
| No | 100 | (53.2) | 81 | (81.8) | 181 | (63.1) | |||||
*
Chi-square statistics, p-values represents a comparison between the HCT survivor group represented at the top of the column and the sibling comparison group.
†
Limited to allogeneic transplants. BM=bone marrow, PBSC=peripheral blood stem cells.