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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Atherosclerosis. 2010 Aug 19;214(1):58–64. doi: 10.1016/j.atherosclerosis.2010.08.054

Figure 1. GX sPLA2 is present in mouse and human AAA.

Figure 1

(A) Sections from aortic tissue removed during surgical repair of AAA were immunostained with 3A5 to detect macrophages, anti-human GX sPLA2, or appropriate control antibodies, as indicated. The upper-left image is a composite of 24 pictures taken at 4× magnification; boxed areas indicate the regions shown at higher (10×) magnification. (B) Sections from the abdominal aorta of an apoE−/− mouse infused with 1,000 ng · kg−1 · min−1 Ang II for 28 days were immunostained with antisera specific for mouse macrophages or anti-mouse GX sPLA2, as indicated (upper panels show cross-section of entire aorta, magnification = 4×; lower panels show region encompassing a break in the elastic lamellae, magnification = 20×). (B) Total RNA was extracted from abdominal aortas of apoE−/− mice infused with saline or 1,000 ng · kg−1 · min−1 Ang II for 10 days and analyzed by real-time RT-PCR. Values shown are mean ± SE; *, p < 0.05.