Skip to main content
. Author manuscript; available in PMC: 2011 Jun 17.
Published in final edited form as: Oncogene. 2010 Apr 26;29(24):3453–3464. doi: 10.1038/onc.2010.127

Figure 1.

Figure 1

Summary of PARK2 mechanism of action and selected known targets of ubiquitination. PARK2 is an E3 ubiquitin ligase that normally facilitates the ubiquitination and subsequent degradation of target proteins. Mutations in PARK2 result in a failure to ubiquitinate target proteins and results in increased levels of these targets. UB denotes a ubiquitin moiety. α-syn, alpha-synuclein; C-Jun, c-Jun N-terminal kinase; PAELR, parkin-associated endothelin receptor-like receptor; RanBP2, RAN-binding protein 2.