Table 1.
Genes Differentially Expressed in Healing Gal-3−/− Compared to Healing Gal-3+/+ Mouse Corneas*
| Difference (x-Fold) | Gene Name | Accession Number |
|---|---|---|
| Cell Adhesion Proteins and Receptors | ||
| 1.7 | Gap junctional protein, gamma 1 (Gjc1) | AF283254 |
| −1.5 | C-type lectin domain family 4, member e (Mincle) | BC003218 |
| −1.5 | Galectin-1 (Lgals1) | NM_008495 |
| Cytokines/Growth Factors and Receptors | ||
| 1.4 | Glial cell line derived neurotrophic factor (GDNF) | NM_010275 |
| −1.7 | Transforming growth factor, beta receptor 1 (TGF-βR1) | NM_009370 |
| −1.5 | Interleukin-1 beta (IL-1β) | M15131 |
| −1.4 | INF-gamma R2 (IFN-γ R2) | NM_008338 |
| −1.4 | ErbB3 | L47240 |
| Regulators of Glycosylation | ||
| 1.5 | N-aspartylglucosaminidase (AGA) | AI853851 |
| 1.6 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (ppGalNAcT3) | NM_015736 |
| 1.4 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (ppGalNAcT7) | AF349573 |
| 1.5 | UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide-beta-1, 4-N-acetylgalactosaminyltransferase (β4GalNAcT2) | NM_008080 |
| 1.5 | Beta-1,3-N-acetylgalactosaminyltransferase 2 (β3GalNAcT2) | AK084275 |
| −1.7 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 (β3GalT5) | NM_033149 |
| −1.5 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (ST6GalNAc1) | NM_011371 |
| −1.4 | Cytidine monophospho-N-acetylneuraminic acid hydroxylase (cmah) | NM_007717 |
| −1.4 | Golgi UDP-GlcNAc transporter (SLC35A3) | BC024110 |
| Extracellular Matrix Proteins | ||
| −2.1 | Fibromodulin (Fmod) | X94998 |
| Miscellaneous Transducers, Effectors and Modulators | ||
| 1.4 | Killer cell lectin-like receptor, subfamily A, member 18 (Ly49R) | AF288377 |
| −1.5 | Phosphoglucomutase 1 (PGM1) | BC008527 |
| −1.7 | Sulfatase 1 (SULF1) | NM_172294 |
| −1.4 | Mannose receptor, C type 2 (Endo180) | U56734 |
*
Genes are considered differentially expressed when there is a difference of >1.3-fold between the geometric mean signal of the healing Gal-3−/− group (n = 3) and the healing Gal-3+/+ group (n = 3). Results of glycogenes marked in bold were confirmed by qRT-PCR.