Figure 3.
Immune response in chimeric recipients (E875, G005 and G190) after lung transplantation to a neoantigen. Antibody responses to the T cell-dependent neoantigen, bacteriophage ΦX174 (phage) were measured in three chimeric lung recipients. Phage was injected intravenously twice, 6 weeks apart (primary and secondary immunizations) at a dose of 3 × 109 PFU/kg body weight, and the production of phage-specific antibody determined. Antibody titers were measured by a neutralizing assay and expressed as rate of phage inactivation (Kv). The geometric mean antibody titers and the 95% confidence interval of normal dogs is indicated by the interrupted line and the shaded area. Percent IgG was determined for serum samples obtained 2 weeks after secondary immunization.
◆- ◆ (E875, 68% IgG), •- • (G005, 68% IgG), □- □ (G190, 100% IgG).