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. Author manuscript; available in PMC: 2010 Dec 21.
Published in final edited form as: Oncogene. 2010 Aug 9;29(42):5741–5754. doi: 10.1038/onc.2010.309

Figure 7.

Figure 7

Schematic representation of the proposed mechanism of MUC4-induced EMT and metastasis of OC. MUC4 induces the FAK activation either directly (unknown mechanism) or by interacting with HER2 cause the activation of MKK7, JNK1/2 and c-Jun and leading to upregulation of N-cadherin. The upregulation of N-cadherin induces the EMT process in OC cells. Furthermore, the N-cadherin downstream signaling of Akt, ERK1/2 and MMP9 may be the primary cause for an increased motility and invasion in MUC4-expressing OC cells.