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. 2010 Nov;19(11):2015–2030. doi: 10.1002/pro.496

Figure 2.

Figure 2

Sequence alignment and relationship among S2P homologs. The sequences of 18 characterized S2P homologs are presented. Only the core TM domains containing the HEXXH and NPDG motifs are shown. A: Sequence alignment in the vicinity of the HEXXH motif. The presumed transmembrane helix (TM) is boxed and the consensus amimo acids are highlighted in gray. B: Sequence alignment for the NPDG motif. C: Unrooted dendrogram of S2P homologs based on the alignment of the HEXXH and NPDG motifs. TMpred (http://www.ch.embnet.org/software/TMPRED_form.html) and PSIPRED Protein Structure Prediction Server (http://bioinf.cs.ucl.ac.uk/psipred/) were used to predict TM helix. The unrooted dendrogram was generated by CLUSTALW (http://align.genome.jp/). The aligned sequences are: H.sapiens S2P (GI:6016601), D. melanogaster S2P (GI:19922044), C. elegans S2P (GI:22859116), C. neoformans Stp1 (BROAD ID: CNAG_05742), A. thaliana EGY1 (GI:15238440), Synechocystis sp. PCC6803 sll0862 (GI:16330216), Synechocystis sp. PCC6803 slr0643 (GI:16331565), A. thaliana AraSP (GI:18402981), E.coli RseP (GI:16128169), V. cholerae Vc-RseP (GI:20978850), P. aeruginosa MucP (GI:146448760), B. bronchiseptica HurP (GI:33601589), C. crescentus MmpA (GI:20978837), B. subtilis RasP (GI:20978800), E. faecalis Eep (GI: 256853722), M. tuberculosis Rv2869c (GI:20978863), B. subtilis SpoIVFB (GI:16079849), M. jannaschii mjS2P (GI:2499926).