Figure 6.

A: 2F_o − F_c electron density map contoured at 1.5σ for L89′F polymorphic substitution in monomer B of PR1_N/DRV complex. The shortened CH…O interaction with Thr31′ is indicated by the broken line. B: Superposition of PR1_N dimer in red against PR1_M dimer in blue. The core of the PR1_N structure including the active site shows excellent agreement with the PR1_M structure. The two structures deviate in the 10s loop, 60s loop, and the flap hinge regions where the majority of polymorphic substitutions map. The flap of monomer A agrees well with that of PR1_M structure, but the flap of monomer B deviates by ∼1 Å. C: The RMS deviations (Å) per residue when compared with those of PR1_M are plotted for the Cα atoms of PR1_N. The two monomers are numbered 1–99 and 101–199. The deviations corresponding to 10s, 60s, and hinge loops for both the monomers and the flap of monomer B are indicated. An interactive view is available in the electronic version of the article. PRO486 Figure 6