Figure 3.

An intracellular surface region with conserved disease associations. C-loop 2 is shown in purple, mapped on the comparative models of NBD1 (dark grey) and NBD2 (light grey) in human P-gp (ABCB1). The previously identified functional histidine is shown in yellow.⁵³ An alignment of sequences containing disease-associated mutations is shown at right with residue coloring indicating sequence conservation; each disease-associated nsSNP is indicated with a red star (Table II).