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Effect of MRP4 variants on transport of [3H]-tenofovir. The percentage of tenofovir efflux (90 min) for each variant relative to the MRP4 reference was determined. Data are mean ± standard deviation calculated from nine to 22 determinations. Significant differences between the reference and the variants were assessed by one-way ANOVA and Bonferroni's multiple comparison test (*P < 0.05, **P < 0.001).
