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. 2010 Dec 12;2011:569034. doi: 10.1155/2011/569034

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Copyright © 2011 Yu-Chang Huang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Proposed model of the epigenetic regulation of the expression of the genes for p16^Ink4a and Arf by JDP2. The exposure of young MEF primary cells to aging stress leads to the accumulation of JDP2. JDP2 binds to histones and inhibits the methylation of H3K27 at the p16^Ink4a/Arf locus. As a result, PRC-1 and PRC-2 fail to form stable repressive complexes and are released from the locus. The consequent expression of p16^Ink4a and Arf in the aged cells leads to growth arrest and senescence stage.