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. 2008 Apr 29;2008:801849. doi: 10.1155/2008/801849

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Copyright © 2008 L. Zhu and M. Bakovic.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Downregulation of the mouse Pcyt2 gene by 25-hydroxycholesterol and the LXR-specific agonist TO901317. (a) C3H10T1/2 cells were cultured in the presence of 25-OH (10 ng/μL) or TO901317 (20 nM–20 μM) for 48 hours. Shown are promoter-luciferase reporter activities from four independent experiments performed in duplicates. The numerical values represent means ±S.D., with significant differences indicated as (*) at P < .05, (**) at P < .01 and (***) at P < .001. (b) Pcyt2 mRNAs (α and β) determined in 25-OH (left panel) and 1 μM TO901317 (right panel) treated cells. (c): Western blot showing that 25-OH (left panel) and 1 μM TO901317 (right panel) treatments of C3H10T1/2 cells reduced total (α + β) and α Pcyt2 proteins.