Table 1.
A summary of the slice electrophysiological techniques used in each brain region to measure the effect of ethanol on GABA release.
| Neuronal type recorded | Type of GABA release measured | Ethanol effect | Reference |
|---|---|---|---|
| Basolateral amygdala (MDN) | mIPSCs | Increased mIPSC frequency | Zhu and Lovinger (2006) |
| Basolateral amygdala (MDN) | sIPSCs | Increased sIPSC frequency | Zhu and Lovinger (2006) |
| Basolateral amygdala | PPR | Decreased PPR | Silberman et al. (2008) |
| Brainstem motor | mIPSC | Increased mIPSC frequency | Sebe et al. (2003) |
| Central nucleus of the amygdala | mIPSC | Increased mIPSC frequency | Roberto et al. (2003), Kang-Park et al. (2007), Nie et al. (2009) |
| Central nucleus of the amygdala | PPR | Decreased PPR | Roberto et al. (2003), Nie et al. (2004) |
| Cerebellar Purkinje (MDN and slice) | mIPSCs | Increased mIPSC frequency | Ming et al. (2006), Kelm et al. (2007), Mameli et al. (2008), Hirono et al. (2009) |
| Cerebellar Purkinje (MDN and slice) | sIPSCs | Increased sIPSC frequency | Criswell et al. (2008), Mameli et al. (2008), Hirono et al. (2009) |
| Cerebellar Purkinje | PPR | Decreased PPR | Kelm et al. (2007), Criswell et al. (2008), Mameli et al. (2008) |
| Cerebellar granule | mIPSCs | Increased mIPSC frequency | Carta et al. (2004) |
| Cerebellar granule | sIPSCs | Increased sIPSC frequency | Carta et al. (2004) |
| Cerebrocortical (MDN) | sIPSCs | No effect | Criswell et al. (2008) |
| Hippocampal CA1 pyramidal | mIPSCs | Increased mIPSC frequency | Li et al. (2006) |
| Hippocampal CA1 pyramidal | sIPSCs | Increased sIPSC frequency | Ariwodola and Weiner (2004), Li et al. (2006) |
| Lateral septal (MDN) | sIPSCs | No effect | Criswell et al. (2008) |
| Lateral septal | PPR | No effect | Criswell et al. (2008) |
| Spinal cord motor | mIPSCs | Increased mIPSC frequency | Ziskind-Conhaim et al. (2003) |
| Spinal cord motor | sIPSCs | Increased sIPSC frequency | Cheng et al. (1999) |
| Substantia nigra (MDN) | mIPSCs | Increased mIPSC frequency | Criswell et al. (2008) |
| Thalamocortical relay | sIPSCs | No effect | Jia et al. (2008) |
| VTA | mIPSCs | Increased mIPSC frequency1 and no effect2 | 1: Theile et al. (2008), 2: Xiao and Ye (2008)2 |
| VTA | sIPSCs | Increased sIPSC frequency | Theile et al. (2008), Xiao and Ye (2008)a |
| VTA | PPR | Decreased PPR | Theile et al. (2008) |
a
Note: The increase in sIPSC frequency was only seen in the presence of a μ-opioid receptor agonist. MDN: mechanically dissociated neurons.