Table 5.
Logistic regression examining the association between HTLD and breast cancer risk
| Chromosome arms | All subjects, n = 440 | Pre-menopausal women, n = 185 | Post-menopausal women, n = 242 | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | |
| 5q | ||||||
| By median | 1.56 (1.03–2.36) | 0.036 | 1.92 (1.00–3.71) | 0.05 | 1.47 (0.84–2.58) | 0.18 |
| By quartiles | ||||||
| Q2 | 1.10 (0.63–1.89) | 1.21 (0.51–2.83) | 0.97 (0.46–2.04) | |||
| Q3 | 1.49 (0.84–2.64) | 1.41 (0.60–3.34) | 1.75 (0.79–3.91) | |||
| Q4 | 1.87 (1.05–3.32) | 0.022* | 3.43 (1.32–8.88) | 0.017* | 1.31 (0.61–2.85) | 0.28* |
| Xp | ||||||
| By median | 1.31 (0.87–1.97) | 0.19 | 1.82 (0.95–3.49) | 0.07 | 1.08 (0.63–1.88) | 0.77 |
| By quartiles | ||||||
| Q2 | 1.24 (0.71–2.18) | 2.94 (1.15–7.55) | 0.64 (0.30–1.38) | |||
| Q3 | 1.24 (0.71–2.17) | 2.16 (0.87–5.37) | 0.84 (0.39–1.81) | |||
| Q4 | 1.81 (1.02–3.21) | 0.06* | 3.98 (1.63–9.70) | 0.005* | 0.89 (0.40–2.00) | 0.94* |
| 8q | ||||||
| By median | 1.37 (0.91–2.06) | 0.13 | 1.63 (0.87–3.05) | 0.13 | 1.26 (0.73–2.19) | 0.41 |
| By quartiles | ||||||
| Q2 | 2.53 (1.41–4.54) | 4.34 (1.72–10.92) | 1.70 (0.77–3.80) | |||
| Q3 | 1.65 (0.95–2.88) | 3.03 (1.19–7.75) | 1.17 (0.57–2.40) | |||
| Q4 | 2.37 (1.35–4.16) | 0.008* | 3.57 (1.44–8.84) | 0.015* | 2.00 (0.94–4.24) | 0.13* |
| 9p | ||||||
| By median | 1.92 (1.26–2.92) | 0.002 | 4.59 (2.29–9.20) | <0.001 | 1.07 (0.61–1.88) | 0.83 |
| By quartiles | ||||||
| Q2 | 0.94 (0.55–1.62) | 1.22 (0.46–3.21) | 1.03 (0.50–2.12) | |||
| Q3 | 1.82 (1.01–3.28) | 7.18 (2.48–20.79) | 0.83 (0.38–1.80) | |||
| Q4 | 1.98 (1.09–3.58) | 0.005* | 4.29 (1.53–11.99) | <0.001* | 1.45 (0.65–3.16) | 0.54* |
| 12p | ||||||
| By median | 1.25 (0.83–1.87) | 0.29 | 2.01 (1.06–3.84) | 0.033 | 0.86 (0.50–1.49) | 0.59 |
| By quartiles | ||||||
| Q2 | 1.21 (0.70–2.11) | 1.31 (0.54–3.18) | 1.10 (0.51–2.36) | |||
| Q3 | 1.28 (0.73–2.24) | 2.29 (0.91–5.74) | 0.82 (0.38–1.75) | |||
| Q4 | 1.46 (0.83–2.58) | 0.19* | 2.25 (0.94–5.40) | 0.037* | 1.00 (0.46–2.20) | 0.81* |
| 15p | ||||||
| By median | 1.18 (0.78–1.78) | 0.43 | 3.06 (1.58–5.95) | 0.001 | 0.58 (0.33–1.01) | 0.05 |
| By quartiles | ||||||
| Q2 | 0.78 (0.45–1.37) | 1.32 (0.50–3.45) | 0.64 (0.30–1.36) | |||
| Q3 | 0.91 (0.51–1.63) | 2.56 (0.99–6.64) | 0.48 (0.22–1.04) | |||
| Q4 | 1.12 (0.63–1.99) | 0.62* | 4.44 (1.70–11.6) | <0.001* | 0.42 (0.19–0.95) | 0.023* |
| 15q | ||||||
| By median | 1.58 (1.05–2.38) | 0.030 | 2.79 (1.44–5.40) | 0.002 | 1.16 (0.66–2.03) | 0.62 |
| By quartiles | ||||||
| Q2 | 1.07 (0.62–1.84) | 1.09 (0.42–2.83) | 0.90 (0.44–1.80) | |||
| Q3 | 1.62 (0.91–2.88) | 2.91 (1.17–7.27) | 1.12 (0.51–2.48) | |||
| Q4 | 1.65 (0.92–2.95) | 0.042* | 2.89 (1.17–7.16) | 0.005* | 1.05 (0.46–2.38) | 0.78* |
ORs were adjusted for age, race, education, household income, physical activity in teens, smoking status, alcohol use and family history of cancer. Q1 is the referent group for computing the ORs. HTLD was defined as the percent of (homologous long RTL − homologous short RTL) divided by (homologous long RTL + homologous short RTL).
*P-for-trend.