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. 2010 Oct 25;20(2):294–300. doi: 10.1093/hmg/ddq464

Figure 1.

Figure 1.

Meclizine protects cells against serum withdrawal-induced apoptosis in mutant huntingtin expressing striatal neurons. (A and B) Cell viability measured by the ATP levels of mutant (STHdhQ111/111) and wild-type (STHdhQ7/7) striatal cells cultured in the presence or the absence of fetal bovine serum (FBS) and co-treatment with 50 µm meclizine for 24 h (n = 3, *P < 0.01). (C) Western blot analysis of protein extract from mutant STHdhQ111/111 striatal cells at three time points after the removal of serum and exposure to DMSO or 50 µm meclizine. (D) Dose–response curve showing fold change in viability of mutant STHdhQ111/111 striatal cells in serum-free media upon treatment with different concentrations of meclizine. Viability was determined by the CellTiter-Glo assay and is expressed as fold change relative to DMSO-treated cells. Solid line represents non-linear regression. Data expressed as the mean ± SD (n = 3 per data point).