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. 2010 Oct 25;20(2):294–300. doi: 10.1093/hmg/ddq464

Figure 4.

Figure 4.

Meclizine protects against neuronal dystrophy in a worm model of polyQ toxicity. (A) Dose–response curves for the rescue of tail mechanosensation (Mec) by increasing dose of meclizine in worms expressing 19Q or 128Q repeat containing N-terminal htt proteins. Data expressed as fold change in tail Mec compared with DMSO treatment. Each data point represents the mean ± SE (n = 3, *P < 0.05). (B) Western blot analysis of protein extract from htt-Q128 expressing worms treated with DMSO or 33 µm meclizine. (C) The htt-Q128 aggregate formation was detected by light microscopy following 33 µm meclizine treatments. At least 180 PLM neurons were scored in 90 worms (n = 3). (D) Fluorescent images of the effect of DMSO or 33 µm meclizine on axonal swelling of htt-128Q expressing worms. Scale bars indicate 5 µm. (E) Axonal swelling in PLM neurons of htt-Q128 expressing worms is observed by light microscopy following DMSO or 33 µm meclizine treatments. At least 180 PLM neurons were scored in 90 worms (n = 3, *P < 0.01).